Simulation and modeling are important tools in developing and evaluating network and communication technologies, and many discrete event simulation (DES) systems have been developed. Each DES is implemented differently and its unique application programming interface (API) with the radio model causes radio models to be heavily tied to a particular DES. Ideally, radio models should be DES-agnostic to allow flexibility in their use, reduce licensing costs, shorten the development cycle, and accelerate the improvement of radio technology. An adapter between the DES and the radio model that supports a plug-in architecture can help achieve this objective. To address this issue, IAI has been awarded a follow-on contract to develop an Interoperability Architecture for Simulators and Radio Models (ISAM). The proposed system has a radio model adapter that supports the complete, automatic, and verified conversion of a wide range of radio models. ISAM creates an automated process for compiling and using existing radio models in any DES, regardless of which DES the radio model was written for. A key innovation is a minimally invasive, multi-stage approach to translating API differences. Further, ISAM has a three-tiered compartmentalized adapter design that reduces complexity, increases flexibility and minimizes duplication of effort. Another key innovation is the capability to easily share models among multiple DESs since the entire adaptation process for a model is performed automatically without requiring user input. ISAM can be an enabling technology for combining legacy radio models with DESs and other components in new ways, thus reducing costs and delays associated with current practices. It can improve the compatibility and flexibility of existing simulation technologies and models, and has already shown success in converting several radio models.