Geo-spatial information is increasingly utilized across diverse fields, ranging from land use planning, government services planning and environmental studies to marketing. Geo-spatial information is also relevant to substance abuse researchers as they explore various hypotheses that involve spatial elements. GISTe is a GIS tool developed by Intelligent Automation Inc. (IAI) under NIDA support that is specialized for use by substance abuse epidemiologists to perform geo-spatial visualization and analysis on data with geo-spatial attributes. It can be used to study novel spatial context of data including geo-temporal trends, clustering, and multivariate models, without requiring elaborate set up and network connectivity. GISTe incorporates the use of the industry standard shapefile format and is powered by IAI’s QuickMaps©. IAI is making a beta release of GISTe available for free download. We encourage researchers to download the application and use it to perform your research. GISTe may be download from GISTe product page.