The success of clinical trials to assess pharmacotherapy treatment for drug abuse depends upon the patient’s adherence to medication schedule and dosage. Traditional compliance monitoring procedures like bioassays and supervised ingestion are time-consuming and expensive. Adherence monitoring is currently aided by commercial off-the-shelf (COTS) electronic pill dispensers with reminders, like MedSmart from e-pills. However, no compliance system exists that can assure researchers, clinical trial investigators or caretakers that the patient has orally ingested the medicine. To address this, IAI has been awarded a new contract entitled, “MEDICAM: Medication Ingestion Compliance and Adherence Monitoring System.” A Smartphone based Medication Ingestion Compliance and Adherence Monitoring (MEDICAM) System will be developed to offer an accurate, affordable, and portable solution for compliance monitoring of pharmacotherapy treatment by medical professionals or caretakers. MEDICAM is enhanced with secured pill dispensing technology that can be integrated with compatible secured pill dispensers. It innovatively uses three technologies, including analysis of Smartphone video and audio data and external psychophysiological sensor data, to provide various degrees of compliance behavior. One or more of them can be applied depending on the medical treatment procedure and compliance requirements. Video analysis techniques can track pill and drinking water glass tracking, to obtain the first level of compliance check. Speech analysis is used for higher levels of compliance check. Finally, the last level of compliance assurance uses physiological sensors to detect significant deviations from the norm, which could indicate possible non-compliance. MEDICAM records and stores non-compliance data and events and reports them unobtrusively using email and text.