Service members are at particular risk for circadian rhythm misalignments, partly due to mission schedule, travel across time zones, and irregular sleep cycles. The Department of Defense is concerned with these circadian rhythm misalignments as they are known to affect judgment, psychomotor skills, and can lead to Post-Traumatic Stress Disorder (PTSD). At present, there is no comprehensive unobtrusive and easy-to-use solution that measures circadian misalignment and automatically administers the appropriate therapy for realignment of circadian rhythm. IAI and the Lighting Research Center at Rensselaer Polytechnic Institute propose to develop an end-to-end Circadian rhythm Monitoring and Regulation device (CMR). CMR uses smart goggles with physiological sensors like heart rate monitor and temperature sensor; activity sensors; calibrated light sensors that collect ecological light/dark exposure patterns; and light regulation that uses electrochromic lenses and side emitting fiber optics to filter out and/or safely deliver circadian effective light as needed. CMR also uses a smartphone/smartwatch application to automatically control the user’s circadian lighting needs and allow the user to wirelessly input relevant information. CMR is compact, lightweight, and requires low maintenance. In addition, it will collect continuous light/dark, activity/rest patterns, and heart rate, which will be used to estimate circadian misalignment. Algorithms, already developed by the LRC team will be leveraged to quantify circadian entrainment or disruption, as well as lighting prescriptions needed to re-entrain the brain’s internal clock. Human factors considerations such as blue light hazard, ergonomic form factor and ambidexterity will be considered in the design. In addition to being of use to service members, CMR has commercial use for improving the health of shift workers and international travelers.