A recent review of military substance abuse treatment and prevention by the Institute of Medicine showed that substance misuse has reached the level of a public health crisis within the armed forces over the last decade. Prescription drug misuse is higher among military personnel than civilians, while the prevalence of illicit drug use is remarkably low among military personnel relative to civilians. IAI and collaborators from the Naval Health Research Center are developing an evidence-based prescription drug-abuse prevention mobile application called MAPDE (Mobile Application for Prescription Drug-Abuse Education) to address the need for reducing prescription drug misuse. The theoretical framework for MAPDE is based on the Elaboration Likelihood Model (ELM) of attitude and behavior change, and it accommodates individual differences in ability and motivation to learn about prescription drug misuse. IAI’s app delivers brief interventions to assess prescription drug use and provides personalized feedback and recommendations. MAPDE teaches core strategies of communication and decision-making, and provides opportunities to practice this skill set. It aims to modify high-risk behavior before either addiction or serious negative consequences occur by providing a confidential environment for service members to learn about reducing prescription drug misuse. MAPDE can also help members access more formal resources by listing military and civilian contacts for assistance and information. This prevention and skills-building tool will be one component of a multi-faceted effort to reduce prescription drug misuse among military members, and to augment in-person medical visits and other educational programs , including IAI’s mSmart project.