Medication non-adherence greatly lowers efficacy and can lead to prolonged illnesses, re-hospitalization, or even death . A personalized, affordable, mobile application that bridges the gap between the provider, pharmacy, and the caregiver, could enhance the efficacy of medication adherence and intervention. To address this need, IAI and its collaborators from The Duke University have developed mSMART, a smartphone application that provides real-time, feedback-based medication tracking by combining behavioral assessment with wireless medication event monitoring and reporting technologies to provide goal-oriented intervention. mSMART is based upon the concept of multiple Adherence Enhanced Interventions (AEI) for short term and long-term adherence change. Educational intervention allows the user to access physician-verified medication dosages, benefits, and side effects . In addition, medication adherence behavioral assessment is followed by either informational intervention or access to the medical provider when a patient is feeling concerned. Further more, psychosocial behavioral assessment is used through Ecological Momentary Assessment (EMA) questions that are remotely logged and analyzed by the provider to offer SMS intervention. Finally, the intervention includes reminders, which can be set by the health care provider or caregiver. The mSMART application’s continued development will include additional automated interventions and an enhanced health care provider portal for assessment management, as well as a long-term pilot study.