Over the last decade, a review by the Institute of Medicine revealed that substance abuse has reached the level of a public health crisis within the armed forces. Prescription drug misuse was found to be higher among military personnel than civilians, while illicit drug use was found to be lower among military personnel relative to civilians. IAI and collaborators from the Naval Health Research Center will continue development of an evidence-based prescription drug-abuse prevention app called MAPDE. MAPDE, or the Mobile Application for Prescription Drug-Abuse Education, will reduce military members’ prescription drug misuse by helping them understand the risks, while enhancing their communication and decision-making skills. It helps users understand the importance of adhering to instructions and those who are reluctant to access more formal resources due to the stigma associated with substance abuse treatment. The theoretical framework for MAPDE is based on the Elaboration Likelihood Model (ELM) of attitude and behavior change. This model accommodates individual differences in ability and motivation to learn about prescription drug misuse. Military members will use MAPDE to understand behaviors that may put them at risk and to prevent high-risk behavior before addiction or serious negative consequences occur. This prevention and skills-building app will augment medical visits and other educational programs as part of a multi-faceted effort to reduce prescription drug misuse. After the first phase of development, a usability study was conducted. The results showed high ratings of perceived ease of use and value, which are good indicators of user acceptability. In the next phase, MAPDE will be developed further and a pilot study will be conducted in a primary care setting to obtain preliminary efficacy results.