Studies have shown that it is important to manage the effects of stress on the mental health and well-being of military personnel. A curriculum must be developed that is sensitive to the time available to military personnel and has the capability to determine which factors, skills, or components are effective at maintaining psychological flexibility. IAI is developing MySELF, Mindfully Mitigating Stress Effects with PsychologicaL Flexibility, an instructional program designed to foster psychological flexibility while teaching effective stress management techniques. MySELF will help warfighters integrate these techniques into their daily lives. Our approach works both bottom-up from the physical and top-down from the cognitive to achieve the desired mind-body connection. Instructional material and exercises take place on a mobile device, making them simple to learn, easy to fit into almost any schedule, and habitual so they do not require much practice. MySELF uses voice-based stress analysis models to prompt employment of techniques and to support the user whenever help is needed. MySELF assesses perceived stress, mindfulness, and psychological flexibility to monitor the user’s state. The technology will have broad applications in military settings and other applications including disaster and crisis management, first response, law enforcement, and humanitarian relief efforts, where personnel are exposed to stress inducing situations.